New approaches for managing inflammation
Inflammation is a fundamental biological process and an essential component of the body’s defense and repair systems, protecting against infection and injury. When tightly regulated, it is essential for health, orchestrating immune defense and tissue repair. However, when inflammation becomes excessive, persistent, or dysregulated, it drives disease rather than resolution. Pathologic inflammation underlies a wide range of serious conditions, from chronic respiratory diseases to cardiovascular, metabolic, and autoimmune disorders, representing one of the most significant unmet needs in modern medicine. Current therapeutic options often rely on broad immunosuppression, which can blunt host defense and fail to address the underlying pathogenic pathways. There is a critical need for new approaches that selectively modulate maladaptive inflammation while preserving protective immunity.