Publications & Presentations

Alonso-Ojembarrena I. et al. 2025. A phase 1b randomized, multicenter, dose determination trial of zelpultide alfa (recombinant human surfactant protein D) in preterm neonates at high risk of developing bronchopulmonary dysplasia. Frontiers in Pediatrics. Volume 13.

September 11, 2025

Manning R. et al. 2022. Characterization of Oligomer Formation of Surfactant Protein-D (SP-D) Using AF4-MALLS. Current Protein & Peptide Science. Volume 23. Issue 12.

November 16, 2022

DePietro M. & Salzberg M. 2022. Commentary: Pattern Recognition Proteins: First Line of Defense Against Coronaviruses. Frontiers in Immunology. Volume 13.

January 25, 2022

Arroyo R. et. al. 2021. Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2 . Biomolecules. Volume 11. Issue 8.

July 28, 2021

Arroyo R. & Kingma P.S. 2021. Surfactant Protein D and Bronchopulmonary Dysplasia: A New Way to Approach an Old Problem. Respiratory Research. Volume 22.

May 8, 2021

Arroyo, R. et al. 2021. Evaluation of recombinant human SP-D in the rat premature lung model. Annals of Anatomy. Volume 235.

May 1, 2021

García-Mouton et al. 2021. Pulmonary Surfactant and Drug Delivery: An Interface-Assisted Carrier to Deliver Surfactant Protein SP-D Into the Airways. Frontiers in Bioengineering and Biotechnology. Volume 8.

January 17, 2021

Arroyo R, Martin-Gonzales A, Echaide M, Jain A, Brondyk W, Rosenbaum J, Moreno-Herrero F, Perez-Gil J. 2018. Supramolecular Assembly of Human Pulmonary Surfactant Protein SP-D. Journal of Molecular Biology Volume 430, Issue 10.

May 11, 2018

King, BA & Kingma, P.S. 2011. Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia. American Journal of Respiratory Cell and Molecular Biology Volume 44, Issue 5.

July 16, 2010

Sato, A, et al. 2010. Surfactant Protein-D Inhibits Lung Inflammation Caused by Ventilation in Premature Newborn Lambs. American Journal of Respiratory Critical Care Medicine Volume 181, Issue 10.

February 3, 2010

Ikegami M. Et al. 2009. Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool size. Journal of Applied Physiology Volume 106 Issue 5.

May 1, 2009

Kingma P.S. et al. 2006. Correction of Pulmonary Abnormalities in Sftpd/ Mice Requires the Collagenous Domain of Surfactant Protein D. The Journal of Biological Chemistry Volume 281. Issue 34.

August 1, 2006

Ikegami, M, et al. 2006. Intratracheal Recombinant Surfactant Protein D Prevents Endotoxin Shock in the Newborn Preterm Lamb. American Journal of Respiratory Critical Care Medicine. Volume 173. Issue 12.

March 21, 2006

Ikegami, M, et al. 2005. Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells. American Journal of Physiology: Lung Cellular and Molecular Physiology. Volume 288. Issue 3.

March 1, 2005

Zhang, L, et al. 2002. Reversibility of Pulmonary Abnormalities by Conditional Replacement of Surfactant Protein D (SP-D) in Vivo. The Journal of Biological Chemistry. Volume 277. Issue 41.

October 1, 2002

Zhang, L, et al. 2001. Activity of Pulmonary Surfactant Protein-D (SP-D) in Vivo Is Dependent on Oligomeric Structure. The Journal of Biological Chemistry. Volume 276. Issue 22.

June 1, 2001

LeVine A.M. et al. 2000. Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung. The Journal of Immunology. Volume 165. Issue 7.

October 1, 2000

Ikegami, M. et al. 2000. Surfactant metabolism in SP-D gene-targeted mice. American Journal of Physiology: Lung Cellular and Molecular Physiology. Volume 279. Issue 3.

September 1, 2000

Kramer, BW, et al. 2001. Surfactant protein A recruits neutrophils into the lungs of ventilated preterm lambs. American Journal of Respiratory Critical Care Medicine. Volume 163. Issue 1.

May 19, 2000

Korfhagen, T.R. et al. 1998. Surfactant Protein-D Regulates Surfactant Phospholipid Homeostasis in Vivo. The Journal of Biological Chemistry. Volume 273. Issue 43.

October 1, 1998